Most Popular Movies 2025
This chart shows the 2025 movie releases that have attracted the most interest on The Numbers web site over the past 24 hours. A share of 100 corresponds to 1 percent of the total views for all 2025 releases.
See also: Domestic Release Schedule for 2025 - Top 2025 Worldwide 
| ← 2024 | Most Popular Overall | Most Anticipated 2025 → | 
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| Chainsaw Man — The Movie: Reze Arc (チェンソーマン レゼ篇) | 
| Director: Tatsuya Yoshihara | 
| Lead Roles: Kikunosuke Toya (戸谷 菊之介) as Denji, Reina Ueda (上田 麗奈) as Reze | 
| Initial Theatrical Release: September 19, 2025 (Wide) by TOHO animation (Japan) | 
| Keywords: Anime, Action Adventure, Demons | 
| Classification: Based on Comic/Graphic Novel, Action, Digital Animation, Contemporary Fiction | 
| Domestic BO: $23,434,408 | 
| International BO: $90,704,660 | 
Synopsis
Denji worked as a Devil Hunter for the yakuza, trying to pay off the debt he inherited from his parents, until the yakuza betrayed him and had him killed. As he was losing consciousness, Denji’s beloved chainsaw-powered devil-dog, Pochita, made a deal with Denji and saved his life. This fused the two together, creating the unstoppable Chainsaw Man. Now, in a brutal war between devils, hunters, and secret enemies, a mysterious girl named Reze has stepped into his world, and Denji faces his deadliest battle yet, fueled by love in a world where survival knows no rules.
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| One Battle After Another | 
| Director: Paul Thomas Anderson | 
| Lead Roles: Leonardo DiCaprio as Bob Ferguson, Sean Penn as Col. Steven J. Lockjaw, Benicio del Toro as Sensei Sergio, Regina Hall as Deandra, Teyana Taylor as Perfidia Beverly Hills, Chase Infiniti as Willa Ferguson-Beverly Hills | 
| Initial Theatrical Release: September 24, 2025 (Wide) by Warner Bros., released as Une bataille après l'autre (France) | 
| Keywords: Filmed in California, United States, Filmed in United States, Kidnap, Rescue, The Past Catching up with You, White Supremacists, Interracial Child, Fugitive / On the Run, Political Activist, Witness Protection, Political Extremism, Action Comedy | 
| Classification: Original Screenplay, Action, Live Action, Contemporary Fiction | 
| Domestic BO: $66,608,876 | 
| International BO: $114,400,000 | 
Synopsis
A former revolutionary battles to save his abducted teenage daughter from the clutches of an old enemy.
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| Tron: Ares | 
| Director: Joachim Rønning | 
| Lead Roles: Jared Leto as Ares | 
| Initial Theatrical Release: October 8, 2025 (Wide) by Walt Disney (Netherlands) | 
| Keywords: Filmed in Canada, Action Adventure, Legacy Sequel, Good vs. Evil, Cybercrimes, Cyber Warfare, Computer Industry, Corporate Malfeasance, Corporate Espionage, Artificial Intelligence, Virtual / Reality Crossover | 
| Classification: Original Screenplay, Action, Live Action, Science Fiction | 
| Domestic BO: $64,735,983 | 
| International BO: $60,294,880 | 
Synopsis
A highly sophisticated Program, Ares, is sent from the digital world into the real world on a dangerous mission, marking humankind’s first encounter with A.I. beings.
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| Demon Slayer -Kimetsu no Yaiba- The Movie: Infinity Castle | 
| Director: Haruo Sotozaki | 
| Lead Roles: Natsuki Hanae as Tanjiro Kamado, Akari Kitō as Nezuko Kamado , Zach Aguilar as Tanjiro Kamado (English Dub), Abby Trott as Nezuko Kamado (English Dub) | 
| Initial Theatrical Release: July 18, 2025 (Wide), released as Demon Slayer -Kimetsu no Yaiba- The Movie: Infinity Castle (劇場版「鬼滅の刃」無限城編) (Japan) | 
| Keywords: Action Adventure, Demons, Anime | 
| Classification: Based on Comic/Graphic Novel, Action, Digital Animation, Fantasy | 
| Domestic BO: $132,613,763 | 
| International BO: $534,437,000 | 
Synopsis
Tanjiro Kamado is a boy who joined an organization dedicated to hunting down demons called the Demon Slayer Corps after his younger sister Nezuko was turned into a demon. While growing stronger and deepening his friendships and bonds with fellow corps members, Tanjiro has battled many demons with his comrades, Zenitsu Agatsuma and Inosuke Hashibira. Along the way, his journey has led him to fight alongside the Demon Slayer Corps’ highest-ranking swordsmen, the Hashira, including Flame Hashira Kyojuro Rengoku aboard the Mugen Train, Sound Hashira Tengen Uzui within the Entertainment District, as well as Mist Hashira Muichiro Tokito and Love Hashira Mitsuri Kanroji at the Swordsmith Village.
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| Black Phone 2 | 
| Director: Scott Derrickson | 
| Lead Roles: Ethan Hawke as The Grabber | 
| Initial Theatrical Release: October 15, 2025 (Wide) by Universal Pictures International (France) | 
| Keywords: Filmed in Canada, Psychological Horror, Serial Killer, Supernatural Horror, 1980s, 1950s, Dream Sequence, Young Child Dealing with the Death of a Parent, Faked Suicide, Camping, Extreme Weather, PTSD, Addiction | 
| Classification: Based on Fiction Book/Short Story, Horror, Live Action, Historical Fiction | 
| Domestic BO: $52,413,805 | 
| International BO: $34,385,503 | 
Synopsis
As Finn, now 17, struggles with life after his captivity, the headstrong 15-year-old Gwen begins receiving calls in her dreams from the black phone and seeing disturbing visions of three boys being stalked at a winter camp known as Alpine Lake. Determined to solve the mystery and end the torment for both her and her brother, Gwen persuades Finn to visit the camp during a winter storm. There, she uncovers a shattering intersection between The Grabber and her own family’s history. Together, she and Finn must confront a killer who has grown more powerful in death and more significant to them than either could imagine.
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| Regretting You | 
| Director: Josh Boone | 
| Lead Roles: Allison Williams as Morgan, Mckenna Grace as Clara, Dave Franco as Jonah, Mason Thames as Miller | 
| Initial Theatrical Release: October 22, 2025 (Wide), released as Ladies Night: Regretting You (Belgium) | 
| Keywords: Romantic Drama, Filmed in Atlanta, GA, Filmed in Georgia, United States, Filmed in United States, Non-Chronological, Romance, Death of a Spouse or Fiancée / Fiancé, Young Child Dealing with the Death of a Parent, Relationships Gone Wrong, Dysfunctional Family, Infidelity, Widow/Widower, Prom | 
| Classification: Based on Fiction Book/Short Story, Drama, Live Action, Contemporary Fiction | 
| Domestic BO: $18,242,388 | 
| International BO: $9,906,054 | 
Synopsis
Morgan Grant and her daughter Clara explore what’s left behind after a devastating accident reveals a shocking betrayal and forces them to confront family secrets, redefine love, and rediscover each other.
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| Springsteen: Deliver Me From Nowhere | 
| Director: Scott Cooper | 
| Lead Roles: Jeremy Allen White as Bruce Springsteen | 
| Initial Theatrical Release: October 22, 2025 (Wide) by Walt Disney (France) | 
| Keywords: Biographical Drama, Biography, 1980s, Singers, Music Industry, You Can't Go Home Again, Dysfunctional Family, Addiction, Mental Illness, Depression, Therapists / Therapy | 
| Classification: Based on Real Life Events, Drama, Live Action, Dramatization | 
| Domestic BO: $11,677,000 | 
| International BO: $6,933,302 | 
Synopsis
A film that chronicles the making of Bruce Springsteen’s 1982 “Nebraska” album when he was a young musician on the cusp of global superstardom, struggling to reconcile the pressures of success with the ghosts of his past. Recorded on a 4-track recorder in Springsteen’s New Jersey bedroom, the album marked a pivotal time in his life and is considered one of his most enduring works—a raw, haunted acoustic record populated by lost souls searching for a reason to believe.
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| The Conjuring: Last Rites | 
| Director: Michael Chaves | 
| Lead Roles: Vera Farmiga as Lorraine Warren, Patrick Wilson as Ed Warren | 
| Initial Theatrical Release: August 28, 2025 (Wide) by Warner Bros. (Finland) | 
| Keywords: Filmed in England, Filmed in United Kingdom, Supernatural Horror, Paranormal Investigation, Based on an UNTRUE Story, Prologue, 1960s, Demons, Pregnant Women, Troubled Pregnancy or Miscarriage, Haunting, Father’s Footsteps, Psychics | 
| Classification: Original Screenplay, Horror, Live Action, Contemporary Fiction | 
| Domestic BO: $176,993,807 | 
| International BO: $310,300,000 | 
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| Shelby Oaks | 
| Director: Chris Stuckmann | 
| Lead Roles: Camille Sullivan as Mia, Sarah Durn as Riley | 
| Initial Theatrical Release: October 9, 2025 (Limited) by Nos Audiovisuais (Portugal) | 
| Keywords: Fantasia International Film Festival 2024, Festival Acquisition, Crowdfunding, Supernatural Horror, Supernatural, Missing Person, Suicide, Paranormal Investigation, Internet, Occult, Kidnap, Sex Crimes, Animals Gone Bad | 
| Classification: Original Screenplay, Horror, Live Action, Contemporary Fiction | 
| Domestic BO: $3,023,333 | 
| International BO: $79,471 | 
Synopsis
A woman’s obsessive search for her missing sister leads her into a terrifying mystery at the hands of an unknown evil.
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| Bugonia | 
| Director: Yorgos Lanthimos | 
| Lead Roles: Emma Stone as Michelle, Jesse Plemons as Teddy | 
| Initial Theatrical Release: October 23, 2025 (Wide) by Universal Pictures (Italy) | 
| Keywords: Filmed in England, Filmed in United Kingdom, Filmed in Greece, Remake, Foreign-Language Remake, Venice Film Festival 2025, Black Comedy, Conspiracy Theory, Kidnap, Surprise Twist, Non-Chronological, Coma, Human Experimentation | 
| Classification: Based on Movie, Black Comedy, Live Action, Science Fiction | 
| Domestic BO: $944,990 | 
| International BO: $1,163,010 | 
Synopsis
Two conspiracy obsessed young men kidnap the high-powered CEO of a major company, convinced that she is an alien intent on destroying planet Earth.
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| Baahubali: The Epic | 
| Director: S.S. Rajamouli | 
| Lead Roles: Prabhas as Mahendra Bahubali / Amarendra Bahubali / Shivudu | 
| Initial Theatrical Release: October 30, 2025 (Limited) (Australia) | 
| Keywords: Action Adventure, Remake, Recut, Prologue, Orphan, Royalty | 
| Classification: Based on Movie, Action, Live Action, Historical Fiction | 
Synopsis
When a lost prince is rescued and raised in exile, he grows up unaware of his past. Years later, he returns to uncover the truth about his father’s murder and his mother’s imprisonment, and must rise to reclaim his place as the rightful king.
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| Weapons | 
| Director: Zach Cregger | 
| Lead Roles: Josh Brolin as Archer Graff, Julia Garner as Justine, Alden Ehrenreich as Paul, Benedict Wong as Andrew, Austin Abrams as Anthony | 
| Initial Theatrical Release: August 6, 2025 (Wide) by Warner Bros., released as Evanouis (France) | 
| Keywords: Supernatural Horror, Supernatural, Witches, Occult, Missing Person, Corrupt Cops, Ensemble, Filmed in Atlanta, GA, Filmed in Georgia, United States, Filmed in United States, Set in Pennsylvania, United States | 
| Classification: Original Screenplay, Horror, Live Action, Contemporary Fiction | 
| Domestic BO: $151,523,003 | 
| International BO: $115,993,455 | 
Synopsis
When all but one child from the same class mysteriously vanish on the same night at exactly the same time, a community is left questioning who or what is behind their disappearance.
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| Roofman | 
| Director: Derek Cianfrance | 
| Lead Roles: Channing Tatum as Jeffrey Manchester | 
| Initial Theatrical Release: October 3, 2025 (Wide), released as Roofman (Грабитель по призванию) (Ukraine) | 
| Keywords: Filmed in North Carolina, United States, Filmed in United States, Ex-soldier, Toronto International Film Festival 2025, Biography, Non-Drama Biographies, Black Comedy, Crime, Crime Spree, Prison, Life on the Outside, Fugitive / On the Run, Romance, Relationships Gone Wrong, Money Troubles | 
| Classification: Based on Real Life Events, Black Comedy, Live Action, Dramatization | 
| Domestic BO: $20,133,471 | 
| International BO: $4,379,723 | 
Synopsis
Jeffrey Manchester, a former Army Ranger and struggling father turns to robbing McDonald’s restaurants by cutting holes in their roofs, earning him the nickname: Roofman. After escaping prison, he secretly lives inside a Toys “R” Us for six months, surviving undetected while planning his next move. But when he falls for Leigh, a divorced mom drawn to his undeniable charm, his double life begins to unravel, setting off a compelling and suspenseful game of cat and mouse as his past closes in.
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| The Bad Guys 2 | 
| Director: Pierre Perifel | 
| Lead Roles: Sam Rockwell as Mr. Wolf, Marc Maron as Mr. Snake, Craig Robinson as Mr. Shark, Anthony Ramos as Mr. Piranha, Awkwafina as Ms. Tarantula | 
| Initial Theatrical Release: July 23, 2025 (Wide), released as The Bad Guys 2 (배드 가이즈 2) (South Korea) | 
| Keywords: Crime Comedy, Heist, Talking Animals, Animal Lead, Going Legit, Wrestling, False Identity, Blackmail, Life on the Outside, Faked Death, Secret Agent, Space Program, Set in Outer Space | 
| Classification: Based on Fiction Book/Short Story, Comedy, Digital Animation, Kids Fiction | 
| Domestic BO: $82,392,360 | 
| International BO: $151,442,895 | 
Synopsis
Our now-reformed Bad Guys are trying (very, very hard) to be good, but instead find themselves hijacked into a high-stakes, globe-trotting heist, masterminded by a new team of criminals they never saw coming: The Bad Girls.
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| Superman | 
| Director: James Gunn | 
| Lead Roles: David Corenswet as Clark Kent / Superman | 
| Initial Theatrical Release: July 9, 2025 (Wide) by Warner Bros. (France) | 
| Keywords: Disrupted by 2023 WGA & SAG Strikes, Filmed in Cleveland, OH, Filmed in Atlanta, GA, Filmed in Ohio, United States, Filmed in United States, Action Adventure, D.C. Comics, Secret Identity, Superman | 
| Classification: Based on Comic/Graphic Novel, Action, Live Action, Super Hero | 
| Domestic BO: $354,184,465 | 
| International BO: $261,451,925 | 
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| Gabby’s Dollhouse: The Movie | 
| Director: Ryan Crego | 
| Lead Roles: Laila Lockhart Kraner as Gabby, Kristen Wiig as Vera | 
| Initial Theatrical Release: September 18, 2025 (Wide) by Universal Pictures (Australia) | 
| Keywords: Family Musical, Family Movie, Animated Inanimate Objects, Living Toys, Filmed in Vancouver, BC, Canada, Filmed in Canada | 
| Classification: Based on TV, Musical, Animation/Live Action, Kids Fiction | 
| Domestic BO: $31,366,025 | 
| International BO: $38,297,698 | 
Synopsis
Gabby heads out on a road trip with her Grandma Gigi to the urban wonderland of Cat Francisco. But when Gabby’s dollhouse, her most prized possession, ends up in the hands of an eccentric cat lady named Vera, Gabby sets off on an adventure through the real world to get the Gabby Cats back together and save the dollhouse before it’s too late.
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| The Long Walk | 
| Director: Francis Lawrence | 
| Lead Roles: Cooper Hoffman as Raymond Garraty, Charlie Plummer as Gary Barkovitch, Mark Hamill as The Major, Ben Wang as Hank Olson, Jordan Gonzalez as Richard Harkness, David Thor Jonsson as Peter McVries, Garrett Wareing as Billy Stebbins, Joshua Odjick as Collie Parker, Tut Nyuot as Arthur Baker, Roman Griffin Davis as Thomas Curley | 
| Initial Theatrical Release: September 11, 2025 (Wide) (New Zealand) | 
| Keywords: Survival Thriller, Filmed in Winnipeg, MB, Canada, Filmed in Manitoba, Canada, Filmed in Canada, Near Future, Dystopia | 
| Classification: Based on Fiction Book/Short Story, Thriller/Suspense, Live Action, Contemporary Fiction | 
| Domestic BO: $35,153,819 | 
| International BO: $13,848,823 | 
Synopsis
The task is simple. Walk or die.
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| Good Boy | 
| Director: Ben Leonberg | 
| Initial Theatrical Release: October 2, 2025 (Limited) by Monster Pictures (Australia) | 
| Keywords: Supernatural Horror, Supernatural, Animal Lead, Death of Other Extended Family, Inheritance, South by Southwest Film Festival 2025, Medical and Hospitals, Terminal Illness, Filmed in New Jersey, United States, Filmed in United States | 
| Classification: Original Screenplay, Horror, Live Action, Contemporary Fiction | 
| Domestic BO: $6,520,212 | 
| International BO: $1,071,947 | 
Synopsis
Our canine hero, Indy, finds himself on a new adventure with his human owner—and best friend—Todd, leaving city life for a long-vacant family home in the country. From the start, two things are abundantly clear: Indy is wary of the creepy old house, and his affection for Todd is unwavering. After moving in, Indy is immediately vexed by empty corners, tracks an invisible presence only he can see, perceives phantasmagoric warnings from a long-dead dog, and is haunted by visions of the previous occupant’s grim death. When Todd begins succumbing to the dark forces swirling around the house, Indy must battle a malevolence intent on dragging his beloved Todd into the afterlife
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| KPop Demon Hunters | 
| Director: Chris Appelhans, Maggie Kang | 
| Lead Roles: Arden Cho as Rumi, May Hong as Mira, Ji Young Yoo (유지영) as Zoey | 
| Initial Theatrical Release: June 20, 2025 (Limited) by Netflix | 
| Keywords: Action Adventure, Demons, Singers, Musicians, Early / Simultaneous Video-on-Demand release | 
| Classification: Original Screenplay, Musical, Digital Animation, Fantasy | 
| Domestic BO: $19,200,000 | 
Synopsis
When they aren’t selling out stadiums, K-pop superstars Rumi, Mira, and Zoey use their secret identities as badass demon hunters to protect their fans from an ever-present supernatural threat. Together, they must face their biggest enemy yet—an irresistible rival boy band of demons in disguise.
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| F1: The Movie | 
| Director: Joseph Kosinski | 
| Lead Roles: Brad Pitt as Sonny Hayes, Damson Idris as Joshua “Noah” Pearce, Kerry Condon as Kate, Javier Bardem as Ruben Cervantes | 
| Initial Theatrical Release: June 25, 2025 (Wide) by Warner Bros. (France) | 
| Keywords: Auto Racing, Action Drama, Filmed in United Kingdom, Filmed in Hungary, Filmed in Italy, Filmed in Belgium, Filmed in Mexico, Filmed in Netherlands, Filmed in Japan, Filmed in Las Vegas, NV, Filmed in United Arab Emirates, Sports Injury, Out of Retirement, Mentor, Rookie, Filmed in United States | 
| Classification: Original Screenplay, Action, Live Action, Contemporary Fiction | 
| Domestic BO: $189,527,111 | 
| International BO: $439,887,191 | 
Synopsis
Sonny Hayes, a Formula One driver who raced in the 1990s, has a horrible crash, forcing him to retire from Formula One and start racing in other disciplines. A Formula One team owner and friend, Ruben, contacts Hayes and asks him to come out of retirement to mentor rookie prodigy Joshua “Noah” Pearce for the Apex Grand Prix team.
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| After the Hunt | 
| Director: Luca Guadagnino | 
| Lead Roles: Julia Roberts as Alma Olsson, Ayo Edebiri as Maggie Price, Andrew Garfield as Hank Gibson, Michael Stuhlbarg as Frederik Olsson | 
| Initial Theatrical Release: October 9, 2025 (Wide) by Sony Pictures, released as Depois da caçada (Brazil) | 
| Keywords: College Professor, Psychological Thriller, The Past Catching up with You, Venice Film Festival 2025, Sex Crimes, Child Abuse, 2010s, College, Suicide | 
| Classification: Original Screenplay, Thriller/Suspense, Live Action, Historical Fiction | 
| Domestic BO: $3,114,476 | 
| International BO: $3,246,759 | 
Synopsis
A college professor finds herself at a personal and professional crossroads when a star student levels an accusation against one of her colleagues, and a dark secret from her own past threatens to come into the light.
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| Truth & Treason | 
| Director: Matt Whitaker | 
| Lead Roles: Ewan Horrocks as Helmuth Hübener | 
| Initial Theatrical Release: October 17, 2025 (Wide) by Angel Studios | 
| Keywords: Nazis, World War II, Political Thriller, Resistance Fighter, 1940s, Jewish, Coming of Age, Filmed in Lithuania | 
| Classification: Original Screenplay, Thriller/Suspense, Live Action, Historical Fiction | 
| Domestic BO: $5,353,387 | 
| International BO: $506 | 
Synopsis
Based on a true story, the film follows Helmuth Hübener, a heroic 16-year-old who fearlessly formed a resistance group with his friends Karl and Rudi after witnessing the arrest of his Jewish friend by the Nazis in Hamburg, Germany.
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| The Fantastic Four: First Steps | 
| Director: Matt Shakman | 
| Lead Roles: Pedro Pascal as Reed Richards/Mister Fantastic, Vanessa Kirby as Sue Storm/Invisible Woman, Joseph Quinn as Johnny Storm/Human Torch, Ebon Moss-Bachrach as Ben Grimm/The Thing | 
| Initial Theatrical Release: July 23, 2025 (Wide) by Walt Disney (France) | 
| Keywords: Disrupted by 2023 WGA & SAG Strikes, Filmed in England, Filmed in Spain, Filmed in United Kingdom, Action Adventure, Origin Story, 1960s, Alternative Dimensions / Parallel universe, End of the World, Marvel Comics, Set in New York City | 
| Classification: Based on Comic/Graphic Novel, Action, Live Action, Super Hero | 
| Domestic BO: $274,286,610 | 
| International BO: $246,350,312 | 
Synopsis
Set against the vibrant backdrop of a 1960s-inspired, retro-futuristic world, Marvel Studios’ “The Fantastic Four: First Steps” introduces Marvel’s First Family—Reed Richards/Mister Fantastic, Sue Storm/Invisible Woman, Ben Grimm/The Thing and Johnny Storm/Human Torch as they face their most daunting challenge yet. Forced to balance their roles as heroes with the strength of their family bond, they must defend Earth from a ravenous space god called Galactus and his enigmatic Herald, Silver Surfer. And if Galactus’ plan to devour the entire planet and everyone on it weren’t bad enough, it suddenly gets very personal.
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| Blue Moon | 
| Director: Richard Linklater | 
| Lead Roles: Ethan Hawke as Lorenz Hart, Margaret Qualley as Elizabeth Weiland | 
| Initial Theatrical Release: October 17, 2025 (Limited) by Sony Pictures Classics | 
| Keywords: Biographical Drama, 1940s, Songwriter, Addiction, Depression, LGBTQ+, Closeted Homosexual | 
| Classification: Based on Real Life Events, Drama, Live Action, Dramatization | 
| Domestic BO: $1,002,898 | 
Synopsis
On the evening of March 31, 1943, legendary lyricist Lorenz Hart confronts his shattered self-confidence in Sardi’s bar as his former collaborator Richard Rodgers celebrates the opening night of his ground-breaking hit musical “Oklahoma!”.
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| Jurassic World Rebirth | 
| Director: Gareth Edwards | 
| Lead Roles: Mahershala Ali as Duncan Kincaid, Scarlett Johansson as Zora Bennett, Jonathan Bailey as Dr. Henry Loomis | 
| Initial Theatrical Release: July 1, 2025 (Wide), released as Jurassic World Rebirth (侏羅紀世界:重生) (Hong Kong) | 
| Keywords: Dinosaurs, Dinosaurs in the Modern World, Action Adventure, Filmed in Thailand, Filmed in Malta, Filmed in England, Filmed in New York, NY, Filmed in United States, Prologue, 2000s, Scientific Experiment Gone Awry, On a Boat, Rescue, Corporate Malfeasance, Betrayal, Pharmaceuticals, Research Scientist, Standalone Sequel | 
| Classification: Original Screenplay, Action, Live Action, Science Fiction | 
| Domestic BO: $339,640,400 | 
| International BO: $528,708,544 | 
Synopsis
Five years after the events of Jurassic World Dominion, the planet’s ecology has proven largely inhospitable to dinosaurs. Those remaining exist in isolated equatorial environments with climates resembling the one in which they once thrived. The three most colossal creatures within that tropical biosphere hold the key to a drug that will bring miraculous life-saving benefits to humankind.